《临床药理学》中国医科大学PPT-drug therapy for reproduction-wy.pptVIP

Factors for the adverse effects in sucking infants The passage of the drug from the maternal blood into the milk The concentration of the drug in the milk The volume of milk sucked The pharmacokinetics of the drug in the infant, particularly its absorption and clearance The inherent toxicity of the drug Factors affecting the transportation of drugs to milk Molecular Weight 200 easily excreted from the milk molecular weight of Insulin and heparin is larger, so it is not easy to discharge from milk Plasma protein binding rate Free type of drug in the mother can be excreted from the milk Lipid