壳聚糖作为药物缓释控释载体的研究进展.pdf

20 4 Vol. 20, No. 4 2008 8 Chinese Bulletin of Life Sciences Aug., 2008 1004-0374(2008)04-0657-04 300070 R318.08 A Research progress of chitosan used as sustained and control drug carrier GAO Xian, MA Shi-kun* (Basic Medical College, Tianjin Medical University, Tianjin 300070, China) Abstract: As chitosan has very good properties, the research of chitosan used as sustained and control drug carrier becomes more and more popular. After loaded by chitosan, these drugs can improve their sustained and control release property, alter their drug-administration-pathway. In this way, they can prolong their drug- administration-interval, degrade their adverse reaction and promote their biological availability. This article introduces the research progress of chitosan and modified chitosan used as common drug and biological macromolecular drug carriers. Key words: chitosan; drug carrier; sustained drug release; control drug release (1,4)-2- - CO H O 2 2 2- -β-D- ( ) [ 3] ( [1] 55% [2]70% 1 ) 2008-02-20 2008-03-25 (2001YY07) * E-mail mashk@tijmu. edu. cn