慢性阻塞性肺疾病并发骨质疏松的常见原因分析-中国骨质疏松杂志.PDFVIP

生旦量亟堕坠盘查!!!!至!!旦笙!!鲞箜!!塑垦!也!Q!堡!P!翌!!堕!!!里!竺!!!!!!!!!!：坠：!! ￡!!!!些!!!!!!!!!!竺：!!!鱼!￡!!生：!!望：!!!!i!!!：!!!!么：!!塑：!!塑!!!!：!!!!：!!：!!i1033 ·综述· 慢性阻塞性肺疾病并发骨质疏松 的常见原因分析 汪为民李红 中图分类号：R563．8文献标识码：A 文章编号：1006-7108(2011)11-1033-04 摘要：慢性阻塞性肺疾病(COPD)患者存在诸多影响骨质代谢的因素，导致骨质疏松的发生，严重威 胁着患者的身心健康。其中吸烟、低氧血症与高碳酸血症、营养不良与低体重、糖皮质激素的应用、免 疫及细胞因子的作用、血液高凝状态、废用性萎缩等都起到一定的作用。可以将骨质疏松当作COPD 肺外疾病表现考虑，也可以认为COPD是骨质疏松的危险因素。尽管慢性阻塞性肺疾病合并骨质疏 松的机制尚未完全明确，但了解二者的相关性对于指导临床治疗，提高慢性阻塞性肺疾病患者的生 存质量有重要意义。 关键词：慢性阻塞性肺疾病；骨质疏松；原因 ofcommoncausesofchronicobstructive disease-associatedWANG Analysis pulmonary osteoporosis First 223300，China Weimin，“Hong，DepartmentofGeriatrics，thePeopleHospitalofHuaian，Jiangsu factors bonemetabolismexistin thechronicobstructive disease Abstract：Manyaffecting pulmonary factorscaninduce and threatenthehealthofthe (COPD)．These osteoporosisseriously patients．Among and andlow weight，glucocorticoidapplication， others，smoking，hypoxemiahypercapnia，malnutrition and status，andduetOdisuse certain immunitycytokines，highcoagulation atrophy play role．Osteoporosis canbeconsideredastheextra diseaseof COPDcanbeconsideredastheriskfactorof pulmonary COPD，or ofchronicobstructive disease themechanism osteoporosis．Although pulmonaryaccompaniedbyosteoporosis isnot ofthe betweenCOPDand is clarified，a osteoporosis completely thoroughunderstandingrelationship forclinicaltreatmentand oflife ofCOPD significant improvementquality patients． Keywords：COPD；Osteoporosis；Factors 慢性阻塞性肺疾病(ChronicOsteoporosis性疾病、内分泌疾病、结缔组织疾病和影响骨代谢的 obstructive dis