心肌脂肪酸氧化酶的基因调控机制及PPAR的作用.PDFVIP

# 1552 # Chinese Journal of Pathophysiology 2002 18( 12) : 1552 - 1555 [ ] 1000- 4718( 2002) 12 - 1552- 05 PPAR 胡 琴 李隆贵 ( 400037) Gene regulation of fatty acids oxidation enzymes in myocardium and the role of PPAR HU Qin LI Long- gui ( Dep artment of Cardiology , X inqiao H osp ital, Third M ilitary Medical University , Chong qing 400037, China) A Review The mammalian fetal heart relies primarily on glucose and pyruvate as substrates for ATP production and it is rapidly transformed to fatty acid - oxidation ( FAO) postnatally . How ever energy metabolic pathways revert to a fetal pattern when cardiac hypertrophy and heart failure developed. This return was called recap itulat ion ultimately it is maladapt ive for the body . The process of FAO was performed under a precise regulating system nuclear transcript ion factors such as PPAR Sp1/ 3 Coup- TF( chicken ovalbumin upstream promoter transcription factor) all take part in the regulation of genes transcription of FAO enzymes. It was identified that the reguction of PPARactivity in hypertrophic myocardium due to pressure overload might result in down- regulation of gene expression of FAO enzyme. The mechanism involved in reinduction of a fe tal gene transcription part icipated in the regulation of myocardial energy metabolism in the development of car diac hypertrophy resulting from pressure overload . [ ] ; ; ; [KEY WOR S] Hypertrophy; Fatty acid ox idation; Myocardium ; Genes [ ] R363 [ ] A : ! ( recapitula [ 2] tion) ∀ ATP 70% 1