优选舌莲胃康胶囊最佳制备工艺.docVIP

院基金：F-456 匡菊香1975-，女，汉族，副教授，硕士 研究方向：中药制剂开发及质量控制 E-mail: HYPERLINK mailto: Tel:优选舌莲胃康胶囊最佳制备工艺 匡菊香1， 蒲顺林2，张倩茹2，杨艳1，杨建文1，周旭美2 (1. 遵义医学院第一附属医院 药剂科， 遵义市 563000；2. 遵义医学院， 遵义市 563000 ) 摘　要 目的：筛选舌莲胃康胶囊的最佳制备工艺。方法：选用L9（34）正交试验，分别对提取和醇沉2个工艺步骤进行筛选；以干膏重量为提取工艺指标；野黄芩苷总提取量为醇沉工艺指标，采用紫外分光光度法测定野黄芩苷的含量。结果：最佳提取工艺为加药材6倍量的水，提取3次，每次1 h；药物水提液过滤、合并、浓缩，再用乙醇沉淀，加入药物浓缩液的6倍量的乙醇，乙醇浓度为65%，沉淀时间为24 h。结论：该提取、醇沉工艺稳定可靠、科学合理，可作为舌莲胃康胶囊的最佳制备工艺。 关键词：正交试验；提取工艺；醇沉工艺 Study on Preparation Technique of Shelianweikang Capsule KUANG Ju-xiang1 , PU Shunlin2, ZHANG Qianru2 , YANG Yan1, YANG Jianwen 1 , ZHOU Xumei 2 , Department of Pharmacy, Affiliated Hospital of Zunyi Medical College， Zunyi 563003，China 2. Zunyi Medical College， Zunyi 563003，China) Abstract Objective: To optimize the preparation technique for Shelianweikang capsules. Methods: The technical conditions for the water decoction was optimized by the orthogonal experiment design L9（34） with dry paste weight as target for decoction process , and the alcohol precipitation was optimized by the orthogonal experiment design L9（34） with scutellarin as target for alcohol precipitation process to survey and evaluate by ultraviolet spectrophotometry. Results: The optimum conditions were as follows: to decocte the crude drugs with 6-fold water, three times, 1 hour each time. The physic liquor extracted by water was filtered, and then precipitated by alcohol of 65﹪ concentration with the amount as six times as extracted physic liquor for 24 h. Then the physic liquor was filtered , concentrated and dried to obtain the dry ointment by microwave vacuum concentration dryer. Conclusion: The preparation procedure is stable and reliable, and it can be used as the optimal preparation technique of Shelianweikang capsules. Key words: Orthogonal design; Extraction technology; Alcohol-Precipitat 慢性萎缩性胃炎(chronic atrophic gastritis, CAG)是一种常见消化系统疾病，随着CAG的病灶加重、恶化，有可能演变为消化系统恶性肿瘤。中医药临床表明预防、治疗CAG疗效独到；舌莲胃康方采用辨症施治、扶正祛邪、标本兼治, 组方合理，治疗CAG疗效明显，能提高机体免疫功能，能缓解CAG患者的临床症状，改