丁香醛保护大鼠脑缺血损伤：抗氧化及抗凋亡效应验证.docVIP

SICENCE新闻发布 作者：Aras Adem Bozkurt 稿号：NRR-D-14-00234 丁香醛保护大鼠脑缺血损伤：抗氧化及抗凋亡效应验证 许多研究证实，黄酮类多酚化合物丁香醛有抗氧化、抗炎作用。土耳其?anakkale Onsekiz Mart大学的Aras Adem Bozkurt所在团队，假设丁香醛的抗氧化和抗炎作用将对缺血脑细胞产生保护作用。实验设计给予脑缺血大鼠腹腔注射丁香醛10mg/kg进行干预。结果发现给药后6和24h，脑缺血大鼠缺血大脑细胞病理损害明显减轻，脑组织超氧化物歧化酶活力和核呼吸因子1水平明显升高，丙二醛水平明显下降，凋亡相关半胱氨酸肽酶caspase-3和-9免疫活性明显降低，神经功能明显改善。说明丁香醛通过抗氧化、抗凋亡途径对大鼠脑缺血损伤起神经保护作用。相关文章发表于《中国神经再生研究（英文版）》杂志2014年11月第21期。 Article: Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties by Aras Adem Bozkurt1, Guven Mustafa1, Akman Tar?k1, Ozkan Adile2, Sen Halil Murat2, K?l?coglu Mesut3, Kalkan Y?ld?ray4, Silan Coskun5, Cosar Murat1 (1 Department of Neurosurgery, ?anakkale Onsekiz Mart University, Canakkale, Turkey; 2 Department of Neurology, ?anakkale Onsekiz Mart University, Canakkale, Turkey; 3 Department of Medical Biochemistry, Ondokuz May?s University, Samsun, Turkey; 4 Deparment of Histology and Embryology, Faculty of Medicine, Recep Tayyip Erdo?an University, Rize, Turkey; 5 Department of Pharmacology, ?anakkale Onsekiz Mart University, Canakkale, Turkey) Bozkurt AA, Mustafa G, Tar?k A, Adile O, Murat SH, Mesut K, Y?ld?ray K, Coskun S, Murat C. Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties. Neural Regen Res. 2014;9(21):1884-1890. 欲获更多资讯： HYPERLINK /Neural Regen Res Syringaldehyde protects cerebral ischemia by anti-oxidative and anti-apoptotic properties Several studies have demonstrated that syringaldehyde is a polyphenolic compound in the flavonoid group that exhibits anti-oxidative and anti-inflammatory effects. Aras Adem Bozkurt, ?anakkale Onsekiz Mart University, Turkey and his team performed a study and hypothesized that syringaldehyde shows neuroprotective effects on ischemic brain cells through its anti-oxidative and anti-apoptotic properties. In their study, rat models of cerebral isch