Chapter-20-钙通道阻滞药-Calcium-channel-blockers.pptVIP

Calcium channel blocker ——通过干扰Ca2+通道活性， 阻滞膜外Ca2+从细胞外经电压依赖性钙通道流入细胞内的药物 又称钙拮抗药 calcium antagonists Calcium is involved in the initiation of smooth muscle, neurotransmitter release, cardiac cell contraction and in the propagation of the cardiac impulse. The calcium channel blockers inhibit the passage of calcium through the voltage gated L-type channels of smooth and cardiac muscle membrane, reduce cytoplasmic free calcium concentration and cause the muscle to relax. Type of calcium channel 钙通道—是细胞膜中蛋白质小孔,易通透Ca2+ 受体门控 高电压激活Ca2+ 通道： L