长链多聚磷酸盐的合成降解检测及临床意义-海南医学.PDF

doi:10.3969/j.issn.1003-6350.2018.17.029 ·综 述· 长链多聚磷酸盐的合成、降解、检测及临床意义 1 1 1 2 杨晓阳 ，万梦婕 ，王智明 ，陈方平 (1. 中南大学湘雅医学院附属海口医院暨海口市人民医院血液科，海南 海口 570208； 2. 中南大学湘雅医院血液科，湖南 长沙 410008) 【摘要】 长链多聚磷酸盐是经多个高能磷酸键连接的线性无机磷酸盐，其磷酸基团从几十到上千不等。长链 多聚磷酸盐普遍存在于包括人体在内的动植物及微生物中，但由于长期缺少转化医学切入点，很长时间被认为是 “分子化石”，无重要的生理功能。直到近期发现其可能通过激活凝血因子Ⅻ以及缓激肽系统等引起炎症和凝血异 常。但目前对长链多聚磷酸盐的认识尚少，为了提高对长链多聚磷酸盐的了解和关注，本文从长链多聚磷酸盐的 合成、降解、检测及临床意义等方面对其进行讨论，希望能起到抛砖引玉的作用。 【关键词】 长链多聚磷酸盐；凝血；炎症；血小板聚集 【中图分类号】R589.4 【文献标识码】A 【文章编号】 1003—6350（2018 ）17—2471—03 Synthesis,degradation,detectionandclinicalsignificanceoflongchainpolyphosphate. YANG Xiao-yang 1, WAN 1 1 2 Meng-jie , WANG Zhi-ming , CHEN Fang-ping . 1. Department of Hematology, Central South University Xiangya School of Medicine Affiliated Haikou Hospital (Haikou Peoples Hospital), Haikou 570208, Hainan, CHINA; 2. Department of Hematology, Xiangya Hospital Central South University, Changsha 410008, Hunan, CHINA 【Abstract】 Long chain polyphosphates are linear inorganic phosphates linked by multiple high-energy phos- phate bonds with phosphate groups ranging from tens to thousands. Long chain polyphosphates are generally found in animals, plants and microorganisms, including humans. However, due to the long-term lack of entry points in translation- al medicine, they have been considered as “molecular fossils”for a long time and have no important physiological func- tions. It has only recently been discovered that they may cause inflammation and coagulation abnormalities by activating the co