阿立哌唑联合帕罗西丁治疗慢性精神分裂症阴性症状临床观察.docxVIP

阿立哌卩坐联合帕罗西丁治疗慢性精神分裂症阴性症状临床 观察 湖南湘西自治州精神病医院416700 摘要：目的：探讨阿立哌卩坐联合帕罗西丁治疗慢性精神分裂症阴性 症状临床观察。方法：选取本院2011年1月到2013年12月屮58例慢性精神分 裂症阴性患者，随机分成治疗组28例，采用阿立哌呼联合帕罗西丁治疗。对照 组30例，采用阿立哌哇治疗。治疗结束后对两组患者釆用阳性与阴性症状量表 (PANSS)评定疗效，用副反应量表(TESS)评定不良反应。结果：治疗组的治 疗效果显著优于对照组，治疗组有效率为82.1%,对照组有效率为53.3%,对比 差异有统计学意义(Plt;0.05)o治疗组和对照组不良反应发生率均稍轻，差异 没有统计学意义(Pgt；0.05)o结论：阿立哌卩坐联合帕罗西丁治疗慢性精神分裂 症阴性症状临床效果显著优于单用阿立哌卩坐，且副反应少。 关键词：阿立哌卩坐；帕罗西丁；慢性精神分裂症；联合治疗 Aripiprazole combined with Palo Shiden in the treatment of chronic schizophrenia with negative symptoms of clinical observation [Abstract]Objective： To investigate the treatment of chronic schizophrenia aripiprazole combined with Palo Shiden clinical observation in negative symptoms.Methods： select the hospital in 2011 January to 2013 12 months in 58 cases of chronic schizophrenia negative patients, randomly divided into the treatment group of 28 cases, treated with aripiprazole treatment combined with Palo Shiden.A control group of 30 cases, treated with aripiprazole treatment.After the end of treatment of two groups of patients with positive and negative symptom scale (PANSS) assessment of efficacy, scale with the side reaction (TESS) to evaluate the adverse reaction.Results： the therapeutic effect of treatment group was better than the control group, treatment group was 82.1%, rate of the control group was 53.3%, there are sign 讦 icant d iff ere nces in contrast (Plt;0.05) .The treatme nt group and the control group, the incidenee of adverse reactions were slightly lighter, the differenee was not statistically significant (Pgt;0.05) .Conclusion： aripiprazole combined with Palo Shiden in the treatment of negative symptoms of chronic schizophrenia with significant clinical effect is better than single aripiprazole, and fewer side effects, [keywordjaripiprazole； Palo Shiden； chronic schizophrenia； combined treatment 慢性精神分裂症的治疗是精神科较为常见的难题，如果没有得到及 吋有效的治疗，患者的自理能力、工作能力等都会受到极人的损害，将会给家庭 和社会带来沉重的负担。阴性症状是慢性精神分裂症的主要表现之一，主要症状 有：情感淡漠、思维贫乏、注意障碍、愉快感缺乏等⑴。阿立哌卩坐作为第三代 非典型抗精神病药物，是多