‘小金海棠’多酚对高脂小鼠肝组织的影响.pdfVIP

上海农业学报2017，33(6)：53-56 Acta Shanghai 1 Agricuhurae 文章编号：1000-3924(2017)06-053-04 ‘小金海棠’多酚对高脂小鼠肝组织的影响 王 鹏，韦月平 (辽东学院农学院，丹东118003) 摘要：采用饲喂高脂饲料建立高脂小鼠模型，‘小金海棠’多酚(MXP)灌胃给药(50mg／kg、100mg／kg)连 续7周检测肝组织中甘油三酯(TG)与总胆固醇(Tc)水平，并观察肝组织形态，最后检测糖脂代谢途径相关蛋白 (IRS、Akt)的表达状况。结果表明：MXP可以降低肝组织中TG和Tc水平，并能明显抑制肝细胞损伤，其中 100 mg／kg组效果较好；更为重要的是MXP可以显著提高IR和IRS的表达，改善糖脂代谢信号通路。 关键词：小金海棠；多酚；高脂 中图分类号：R282．71文献标识码：A fatliver EffectsofMalus on tissueofmouse xiaojinensispolyphenols high WANG Peng，WEIYue—ping 11 (AgriculturalCollege，EasternLiaoningUniversity，Dandong8003，China) micemodelwasestablished dietandMXP Abstract：Hyperlipemia byfeedinghigh—fat gavage and100 treatedtomicefor7weeks．Thelevelsof administration(50mg／kg mg／kg)were total livertissuewere the oflivertissueswas cholesterol(TC)in detected，andmorphology metabolismwas ofrelated the of and detected．Theresults expression proteins(IRS，Akt)inpathwayglucoselipid showedthatMXPcouldreducethelevelofTGandTCinlivertissueandinhibitthe oflivercells injury effectof100 wasbetter．More could the obviously．The mg／kggroup importantly，MXPsignificantlyimprove ofIRandIRSand the of metabolism． expression improve signalingpathwayglycolipid words：Malu