中药单体抗肝纤维化作用研究进展-环球中医药.PDF

环球中医药2016年9月第9卷第9期摇 Global Traditional Chinese Medicine,September2016,Vol郾9,No郾9 1摇149 ·综述 · 中药单体抗肝纤维化作用研究进展 郭雨菲摇 李雪摇 迟莉 揖摘要铱摇 本文通过查阅近几年国内外相关文献,对较为新颖的10种中药单体抗肝纤维化的作 用及机制进行分析和综述。 这10种单体包括橙皮苷、羟基红花黄色素A、灯盏花素、番茄红素、甲基 莲心碱、木犀草素、青蒿琥酯、人参皂苷Rg1、人参皂苷Rb1、红景天苷,经分析,这 10 种中药单体作 用特点各有不同,但对肝纤维化均具有一定的治疗效果;目前对这些中药单体的研究以药效学为 主,机制的研究还较少。 本文可为未来治疗肝纤维化的新药研发方向提供参考。 揖关键词铱摇 肝纤维化;摇 中药单体;摇 作用机制 揖中图分类号铱摇 R285摇 揖文献标识码铱摇 A摇 doi:10郾3969/ j郾issn郾1674鄄1749郾2016郾09郾040 Research advance on the effect of Chinesemedicinemonomeron anti鄄hepaticfibrosis摇 GUO Yu鄄fei, LI Xue,CHI Li.摇 Major of Traditional Chinese Medicine,School of Traditional Chinese Medicine,Capital Medical University,Beijing 100069,China Corresponding author:CHI Li,E鄄mail163.com 揖Abstract铱摇 This paper is to review the recent research progress in domestic and abroad of Chinese medicine monomer for the treatment of liver fibrosis. The effect and mechanism of 10 kinds of traditional Chinese herbal medicine on hepatic fibrosis are analyzed and summarized. The monomer including Hesperidin, Hydroxysafflor yellow A, Breviscapine, Lycopene, Nerefine, Luteolin, Artesunate, Ginsenoside Rg1,Ginsenoside Rb1 and Salidroside. The ten kinds of Chinese medicine monomer have their uniquecharacteristicsandallhavecertaineffectinthetreatmentofliverfibrosis. Atpresent,thestudy on the Chinese medicine monomer is mainly based on pharmacodynamics,but the mechanism is still less. This paper canprovidereferencefor thefuture development of new drugsfor thetreatment of liverfibrosis. 揖Key words铱摇 Hepaticfibrosis;摇 Chinese medicine monomer;摇 Mechanism 摇 摇 肝纤维化是多种慢性肝脏疾病的共同阶段。 单体治疗肝纤维化的报道进行综述。 多种因素引起肝细胞的损伤,激活枯否细胞和窦内 1摇 橙皮苷 皮细胞,分泌细胞因子,进而激活肝星状细胞,大量 合成以胶原为主的细胞外间质,沉积在肝内,导致 橙皮苷(hesperidin)为存在于陈皮、柑桔、代代花 肝纤维化的发生。 肝纤维化的发生涉及多个细胞