冠心病患者载脂蛋白A5水平与脂联素和空腹胰岛素之间的关系-心血管内科专业论文.docxVIP

硕士学位论文 硕士学位论文 中文摘要 1．冠心病组血清ApoA5和脂联素水平显著低于健康对照组 (230．06___115．8ng／ral和3．03+1．85ug／ml比324．43___151．79ng／ml和 4．12±2．48ug／ml，P均O．05)；而冠心病组的FINS水平和HOMA-IR 指数均显著高于对照组(9．85±5．94mu／l和2．71+1．58比7．85± 3．04mu／l和1．69±0．71，P均O．05)。 2．直线相关分析显示：ApoA5浓度与年龄、TG、FINS和HOMA- IR指数均呈负相关(r分别为_0．294，-0．268，-0．222和．0．254；P均 0．05)；与卸DI，．C呈正相关(仁O．38，P0．01)；与脂联素无相关 性(PO．05)。 3。采用偏相关分析对年龄进行校正后，发现hpoa5仍与TG、 FINS和HOMA-IR指数呈负相关(相关系数r分别为．o．23，．0．22和 加．24，P均0．05)，与HDL-C成正相关(r=0．33，P0．05)。 4．采用单变量Logistic回归分析，筛选出冠心病危险因素的候 选变量为脂联素、糖尿病和I-IDL-C，Apoa5浓度不是影响冠心病发 病的主要危险因素(OR=0．996，95％CI=0．990．1．003，嗍．271)． 结论： 1．冠心病患者血清ApoA5和脂联素水平降低，FINS水平增高。 2．血清ApoA5浓度与TG和FINS水平呈负相关，与HDL-c水平 呈正相关，与脂联素水平无明显相关性。 3．ApoA5不但影响血脂代谢，而且可能与胰岛素抵抗有关。 4．ApoA5可能不是影响冠心病发病的主要危险因素。 关键词：载脂蛋白类：血脂；甘油三酯；脂联素；胰岛素。 Ⅱ 硕士学位论文 硕士学位论文 英文摘要 Background：The apolipoprotein A5(APOA5)was the newest apolipoprotein discovered in 2001．It has been identified that the genotype ofAPOA5 was closely associated with the levels oftriglyceride Crc)in human,and the rare allele c：Lrliers presented higher TG levels than the noncarriers．Some other reports revealed that the genovariation of ApoA5 may result in decreasing plasma levels of high density lipoprotein cholesterol 0-mL-C)．It is known to all that high TG and low HDL-C levels are indepentant risk factors for coronary heart disease (cx-iD)，and such abnormal Hpid profiles always accompany with insulin resistance．So the association Of APOA5 with CHD and diabetes attracted researchers’attention for the past few years．Besides th她a hormone secreted fxom adipocyte called adiponectin also participates in the metabolism of glucose and lipids，and the levels of adiponectin were found to be lowered in patients with CHD and diabetes．However,the relafionship between the concentrations of APOA5 and the levels of insulin and adiponectin are unclear，and there are very few reports referring to this． objectives：T