日本血吸虫SjPrx1的制备与结晶学研究.docVIP

日本血吸虫SjPrx1的制备及结晶学研究 黄符燕1,2，李攀1,2，彭云1,2，吴群峰1,2，范小林1,2，李勋1,2，李永东1,2* 1江西省有机药物化学重点实验室 江西赣州 341000 2赣南师范学院化学化工学院 江西赣州 341000 *Email: HYPERLINK mailto:ydli2011@163.com ydli2011@163.com 日本血吸虫病（Schistosomiasis）是一种严重危害我国人民生命健康的传染性疾病。血吸虫生存在有氧环境，需要有效的机制来维持细胞的氧化还原平衡。日本血吸虫硫氧还蛋白过氧化物酶SjPrx1属2-Cys类型。该蛋白酶表达定位于血吸虫体被，研究结果表明，SjPrx1蛋白酶的抑制将使血吸虫对过氧化氢和多种过氧化物产生敏感反应 ADDIN EN.CITE EndNoteCiteAuthorKumagai/AuthorYear2009/YearRecNum33/RecNumrecordrec-number33/rec-numberref-type name=Journal Article17/ref-typecontributorsauthorsauthorKumagai, T./authorauthorOsada, Y./authorauthorOhta, N./authorauthorKanazawa, T./author/authors/contributorsauth-addressSection of Environmental Parasitology, Department of International Health Development, Division of Public Health, Tokyo Medical and Dental University Graduate School, Japan. tkuma.vip@tmd.ac.jp/auth-addresstitlestitlePeroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide/titlesecondary-titleMol Biochem Parasitol/secondary-titlealt-titleMolecular and biochemical parasitology/alt-title/titlespages26-31/pagesvolume164/volumenumber1/numberkeywordskeywordAnimals/keywordkeywordBenzene Derivatives/pharmacology/keywordkeywordFree Radical Scavengers/metabolism/keywordkeywordGene Expression Regulation/drug effects/keywordkeywordHydrogen Peroxide/*metabolism/keywordkeywordNitric Oxide/*metabolism/pharmacology/keywordkeywordParasitic Sensitivity Tests/keywordkeywordPeroxiredoxins/*metabolism/keywordkeywordRNA Interference/keywordkeywordRNA, Double-Stranded/pharmacology/keywordkeywordSchistosoma japonicum/drug effects/genetics/*metabolism/keywordkeywordSurvival Analysis/keywordkeywordtert-Butylhydroperoxide/pharmacology/keyword/keywordsdatesyear2009/yearpub-datesdateMar/date/pub-dates/datesisbn0166-6851 (Print)#xD;0166-6851 (Linking)/isbnaccession-nuaccession-numurlsrelated-urlsurl/entrez/query.fcgi?cmd=Retrieveamp;db=PubMedamp;dopt=Citationamp;list_uids/url/related-urls/urlslan