2019年基因多态性与冠心病课件.pptVIP

Gene Polymorphisms and Coronary Heart Disease;Coronary Heart Disease is still the No. 1 killer in the world.;Genetics;Age;But only in 5% of hereditary CHD, the gene background was clear. In the others, each genetic factor played a minor role in occurrence and development of the disease. Rare mutations (e.g., in the LDLR and APOE genes) may have a major effect, whereas genes belonging to normal polymorphism have only a moderate effect. But even genes with only a slight effect can be clinically important in combination with other genes. The importance of polymorphism analyses will increase sig