微泡对高强度聚焦超声声压场影响的仿真研究-应用声学.PDF

第 35 卷 第 5 期 Vol. 35, No.5 2016 年9 月 Journal of Applied Acoustics September, 2016 ⋄ 研究报告⋄ 微泡对高强度聚焦超声声压场影响的仿真研究 喻波涛 常诗卉 曾苗苗 陶敏慧 菅喜岐 (天津医科大学生物医学工程与技术学院 天津 300070) 摘要 微泡对高强度聚焦超声(HIFU) 治疗焦域具有增效作用，而HIFU 治疗中不同声学条件下微泡对HIFU 形成声压场的影响尚不清楚。本文基于气液混合声波传播方程、Keller 气泡运动方程、时域有限差分(FDTD) 法和龙格-库塔(RK) 法数值仿真研究输入声压、激励频率、气泡初始空隙率和气泡初始半径对HIFU 形成声 压场的影响。研究结果表明，随着输入声压的增大，焦点处声压升高但焦点处最大声压与输入声压的比值减 小，焦点位置几乎不变；随着激励频率和气泡初始半径的增大，焦点处声压升高且焦点位置向远离换能器方向 移动；随着气泡初始空隙率的增大，焦点处声压降低且焦点位置向换能器方向移动。 关键词 高强度聚焦超声，微泡，空化，空隙率，数值仿真 中图分类号: R318.5 文献标识码: A 文章编号: 1000-310X(2016)05-0417-09 DOI: 10.11684/j.issn.1000-310X.2016.05.006 The simulation study of the effect of microbubbles on high intensity focused ultrasound acoustic pressure field YU Botao CHANG Shihui ZENG Miaomiao TAO Minhui JIAN Xiqi (Department of Biomedical Engineering and Technology, Tianjin Medical University, Tianjin , China) Abstract The synergy effect of microbubbles was used to enhance HIFU treatment focal region. However, the effect of microbubbles on HIFU acoustic pressure field in different acoustic conditions during HIFU therapy is not clear. In this paper, the effect of input acoustic pressure, exciting frequency, initial bubble void fraction and initial bubble radius on the acoustic pressure field of HIFU was discussed based on the gas-liquid mixing acoustic propagation equation, Keller bubble motion equation, the finite difference time domain (FDTD) method and Runge-Kutta (RK) method. The results show that, as the input acoustic pressure increasing, the acoustic pressure at focus increases but the ratio of maximum acoustic pressure