细胞凋亡与疾病-病理学.pptVIP

* * * * * * * * * * * * * * * * * * * * * * * * * * * The ladder pattern can only be demonstrated in apoptotic cells where a specific cleavage process takes place. This cartoon should give some insight in the DNA cleavage on the molecular level. Nuclear DNA is attached to the histon-complex with a definite length. DNA and Histones form the so-called nucleosomes. Nucleosomes are connected by linker DNA of about 200 bp. The linker-DNA is - in contrast to the histon-bound DNA - easily accessible to Ca2+ dependent endonucleases that are activated during the apoptotic process. The cleavage of the D