恶性肿瘤者促红细胞生成素浓度检测和相关性分析.docVIP

恶性肿瘤患者促红细胞生成素浓度检测和相关性分析※ ※通讯作者：冯岗 e-mail:fenggangmych@ 基金项目：四川省卫生厅科研基金 NO：050273 冯岗1 邓文斌2 唐华2 王晋1 张羽1 杜小波1 姚兵1 李慧1 四川省绵阳市中心医院，四川，绵阳，621000 1肿瘤科 2 检验科 摘要 目的 了解肿瘤患者体内促红细胞生成素的水平，为临床治疗提供参考. 方法 我们采用酶联免疫法测定了77肿瘤患者的促红细胞生成素(erythropoietin, EPO)含量和血常规，同时以20例健康查体的正常人为对照。分析EPO含量同血常规结果的关系。结果 健康人群的EPO含量为17.32±10.20mIU/mL，恶性肿瘤患者为44.34±35.26 mIU/mL，P﹤0.01。其中不贫血的肿瘤患者EPO含量为21.92±14.35 mIU/mL，贫血的肿瘤患者EPO含量为51.18±36.95 mIU/mL，P﹤0.01。曾经做过化疗的肿瘤患者EPO含量为28.08±18.23 mIU/mL，没有化疗的患者为59.39±40.41 mIU/mL，P﹤0.01。行含铂方案化疗患者的EPO含量为22.26±14.26 mIU/mL，不含铂方案化疗的患者为37.64±20.44 mIU/mL，P＝0.011。经过相关性分析发现，恶性肿瘤EPO含量同HGB和HCT的相关系数分别为－0.581和－0.548,P=0.01。结论 肿瘤患者EPO水平比正常人显著升高，化疗特别是含铂方案化疗会导致EPO明显降低。肿瘤患者EPO含量同HGB和HCT线性负相关而且可能同肿瘤患者的预后有关。 关键词 促红细胞生成素 肿瘤性贫血 Study on the level of serum erythropoietin in cancer patient Feng Gang, Deng Wenbinig, Tang Hua, Wang Jin, Zhang Yu, Du Xiaobo, Yao Bin, Li Hui Department of cancer, Mian Yang center hospital, Shi Chuan Mian Yang, 621000 Abstract： Objective: To Study on the level of serum erythropoietin in cancer patient. Methods: We check the erythropoietin and the hemogram in 77 cancer patients and 20 cases of healthy volunteers by ELISA. The relationship between EPO and hemogram was analyzed. Result: The serum Epo level in healthy volunteers and cancer patients was 17.32±10.20mIU/mL and 44.34±35.26 mIU/mL, P﹤0.01. The EPO level in cancer patients with anemia and the others is 51.18±36.95 mIU/mL and 21.92±14.35 mIU/mL, P﹤0.01. The serum EPO in cancer patients with or without chemotherapy is 28.08±18.23 mIU/mL and 59.39±40.41 mIU/mL，P﹤0.01. The coefficient correlation between the EPO and HGB and HCT is －0.581 and －0.548. Conclusion: The serum EPO in cancer patient was much higher than that in healthy volunteers. Chemotherapy would reduce The EPO level. The serum EPO had coefficient correlation with HGB and HCT, and might be used as prognosis. Key words: erythropoietin, anemia of neoplasm 研究发现，促红细胞生成素(erythropoietin, EPO)主要有肝和肾脏产生，通过调节红细胞产生和丢失来保持红细胞整体平衡[1]。EPO受乏氧的调节，在肿瘤患者体内