汕头大学医学院药理学精品课程 Thyroid and Antithyroid Drugs.pptVIP

Thyroid and Antithyroid Drugs GAO Fen-Fei Foreword Thyroid hormones includes tetraiodothyronine (四碘甲腺氨酸,T4; thyroxine,甲状腺素) and triiodothyronine(三碘甲状腺原氨酸,T3). For growth and development(生长发育) and for regulation of energy metabolism. Structure Activity Relationship Thyroid Physiology Iodide Metabolism Iodide (I-) intake is via the gastrointestinal tract from food, water, or medication. The recommended daily adult intake is 150μg (200μg during pregnancy). The thyroid gland takes up about 75μg a day for hormone secretion. Biosynthesis of Thyroid Hormone Iodide trapping(摄取): iodine pump, inhib