32种新硫色满酮衍生物对肿瘤细胞的细胞毒作用及其作用机制研究.pdfVIP

Abstract Abstract We have investigated the anti-proliferative activities of 32 Novel synthesized Thiochromanone Derivatives in vitro. MTT assay was used to test the inhibitory effect of 32 compounds on 13 tumor cell lines. 6 tested chemicals (18-22 45) showed cell toxicity to 11 human tumor cell lines ( A549, SGC-7901, BGC-823, K562,U937, Hela, MCF-7, HepG-2, A375, LS174T, HT1080 786O ), and the half maximal inhibitory concent