精馏回收制药废液中四氢呋喃和甲醇工艺的模拟与实验.docxVIP

研究开发精馏回收制药废液中四氢呋喃和甲醇工艺的模拟与实验郑纯智，李 锋，文颖频，刘晓云（江苏技术师范学 研究开发 精馏回收制药废液中四氢呋喃和甲醇工艺的模拟与实验 郑纯智，李 锋，文颖频，刘晓云 （江苏技术师范学院化学与环境工程学院，江苏 常州 213001） 摘 要：以 ChemCAD 软件对含有四氢呋喃、甲醇和水的制药废液的萃取精馏分离进行了模拟。以 ChemCAD 软件确定乙二醇为萃取剂，采用三塔流程分离该混合物。首先模拟以具有 24 块理论板的精馏塔进行萃取精馏从 混合物中分离出四氢呋喃，废液在第 17 块板以饱和液体进料，萃取剂在第 2 块板以饱和液体进料，溶剂比采用 1.65，回流比为 1.5，四氢呋喃回收率可达 99.5%。萃取剂乙二醇回收所需塔板数为 5 块，甲醇回收所需塔板数 为 18 块。通过实验验证了萃取精馏模拟结果的可靠性。 关键词：ChemCAD；萃取精馏；四氢呋喃；甲醇；模拟 中图分类号：TQ 028.1+3 文献标志码：A 文章编号：1000–6613（2010）12–2260–05 Modeling of and research on recovery of tetrahydrofuran and methanol from pharmaceutical wastewater by the extractive distillation ZHENG Chunzhi，LI Feng，WEN Yingpin，LIU Xiaoyun （School of Chemical and Environment Engineering，Jiangsu Teachers University of Technology， Changzhou 213001，Jiangsu，China） Abstract：Extractive distillation of pharmaceutical waste water containing tetrahydrofuran，methanol was simulated with the ChemCAD software. Glycol was chosen as extractant，and a process with three towers was designed for seperating the mixture. Extractive distillation of tetrahydrofuran separation from the mixture of tetrahydrofuran，methanol and water was modeled with a tower with 24 theoretical plates，the modulate result indicated that tetrahydrofuran recovery could be up to 99.5% with the conditions as follow. The mixture was fed at the 17th plate at its boiling point，the extractant was fed at the second plate at its boiling point，solvent ratio was 1.65 and reflux ratio was 1.5. The glycol recovery tower needed five plates，and the methanol recovery tower needed eighteen plates. The reliability of the extractive distillation modeling result was verified by experiment. Key words：ChemCAD；extractive distillation；tetrahydrofuran；methanol；modeling 方法[1]是先用水作为萃取剂，双塔分离得到 THF 与 水的共沸混合物，然后再对该混合物以加盐萃取精 馏法进行双塔分离，该法流程较复杂；第二种方 法[2]是将 THF 与水的共沸混合物先加盐分相，再浓 缩回收盐溶液，该法比较新颖，但所得 THF 的含水 量接近 1%，偏高。许金全等[3]先用某未知萃取剂经 四氢呋喃（THF）是一种优良的溶剂，在化工 行业中应用广泛。THF 作为溶剂在反应中使用后， 经常会混入水、甲醇等物质。但 THF 能与多种物质 形成共沸物，导致其分离回收较难，而制药行业对 THF 溶剂纯度要求更高。 由于不同工艺产生的 THF