骨髓细胞移植联合环磷酰胺诱导胰腺移植大鼠免疫耐受的试验-Core.PDF

( ) 2011; 42(1) : 106 108 J Sichuan Univ (Med Sci Edi) 1 1 2 1 1 1 罗 琪 , 卢明珠 , 罗凌涛 , 傅毓玲 , 傅锦波 , 黄正接 1 ( 361004) ; 2 2006 ( 361005) (BMC) (CTX) (ST Z) 45 mg/ kg BN 1 SD , BN , 20 BN 1 4 , 5 : ; : 1 d 150 mg/ kg CTX; : 8 8 BM C 2.0 10 ; : BMC 2. 0 10 , 1 d 150 mg/ kg CTX, 2 , , + V11 T (7. 8 1. 2) d, ( 8.2 1.6) d, ( 8. 8 1. 4) d, ( 18 2. 2) d, , + (P 0.05) V11 T (2.5 0. 3) % , ( P 005) , , ( 10.0 2. 3) % , 3 BMC CT X , , Immune Tolerance Induced b Bone Marrow Cell Transplantation Combined with Use of C clophosphamide in Diabetic 1 1 2 1 1 Rats with Pancreatic Transplantation L UO Qi , L U M ingz hu , L UO L ingtao , F U Yuling , F U J inBo , H UA N G Zhengj ie 1 . 1. D ep a tment of Gene al Su ge y , Zhongshan H osp ital Af f iliated to X iamen Unive sity , Xiamen 361004, China; 2. D ep a tment of Clinical M edicine, M edical Cellege of X iamen Unive s ity , Xiamen 361005, China Corresponding author, Email:h74zj@ 126. com Abstract Objective T o study the immune tolerance induced by bone marrow cell transplantation combined wit h shortterm use of cyclophosphamide after pancreatic transplantation in diabetic rats. Methods Type diabetes mellitus was induced in BN rats w ith streptozotocin ( STZ ) intraperitoneal injection at a single dose of 45 mg/ kg. Pancreatic tran