长时间电刺兔骶神经根不会造成其损伤.doc

SICENCE新闻发布 作者：闫鹏 稿号：NRR-200-14 莆长时间电刺激兔骶神经根不会造成其损伤 蒇 螂中国吉林大学闫鹏博士所在课题组前期研究发现，应用阳极阻滞技术电刺激截瘫兔骶神经根可使其产生生理性排尿，重建膀胱排尿功能，但长时间的阳极阻滞电刺激对骶神经根有无损伤，还需进行验证。该课题组进一步以短时间连续电刺激的方式模拟临床中长时间慢性电刺激方式干预T9-10完全脊髓损伤模型新西兰兔。结果发现与正常新西兰兔相比，脊髓损伤模型兔经电刺激后骶神经前根中神经细胞结构无明显改变，且其中细胞凋亡相关蛋白Bax，Bcl-2和Caspase-3的表达也未发生明显改变。作者认为，兔骶神经根神经元细胞能很好耐受这一刺激量而不会出现损伤，即使是长时间的阳极阻滞电刺激对骶神经根也无明显损伤。相关文献发表于《中国神经再生研究（英文版）》杂志2014年6月第12期。 腿 葿免疫组化显示，对完全脊髓损伤模型兔以短时间连续电刺激的方式模拟临床中长时间慢性电刺激后，其骶神经前根中Bcl-2的表达无明显变化 薇 膃Article: Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits, by Peng Yan1, 2, Xiaohong Yang1, Xiaoyu Yang1, Weidong Zheng2, Yunbing Tan2 (1 Jilin University, Changchun, Jilin Province, China; 2 People’s Hospital of Jilin Province, Changchun, Jilin Province, China) 羁Yan P, Yang XH, Yang XY, Zheng WD, Tan YB. Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits. Neural Regen Res. 2014;9(12):1217-1221. 膈欲获更多资讯： 蚇Neural Regen Res 薄Prolonged electrical stimulation causes no damage to sacral nerve roots in rabbits 荿 羇Previous studies have shown that, anode block electrical stimulation of the sacral nerve root can produce physiological urination and reconstruct urinary bladder function in rabbits. However, whether long-term anode block electrical stimulation causes damage to the sacral nerve root remains unclear, and needs further investigation. In a recent study reported on the Neural Regeneration Research (Vol. 9, No. 12, 2014), Dr. Peng Yan and co-workers from Jilin University, China established a complete spinal cord injury model in New Zealand white rabbits through T9–10 segment transaction, and these model rabbits were given continuous electrical stimulation for a short period and then chronic stimulation for a longer period. Results showed that compared with normal rabbits, the structure of nerve cells in the anterior sacral nerve roots was unchanged in spinal cord injury rabbits after electrical stimulation.