中国常见过敏原的分析研究.ppt

* 蟑螂过敏原和屋尘螨交叉反应 159/1236 (12.9%) 蟑螂皮试阳性的患者可以检测到特异性IgE（0.35 kU/L) 只有18个患者的蟑螂特异性IgE含量大于4.5 kU/L Cross-inhibition between Der p, Bla g and Per a High IgE cross-reactivity between American and German cockroach Few patients has cockroach as primary sensitizing source (group 1) Few patients has Der p as primary sensitizing source (group 4) 50% of patients seems to be sensitized to both Der p and cockroach (group 2) Group 3 show full cross-reactivity between Der p and cockroach – not possible to identify primary sensitizing source Sun et al. Chin Med J 2010 蟑螂过敏原小结 虽然全国范围内，患者对蟑螂的皮试反应阳性率比较高，但全国范围内（除海南外）蟑螂过敏原的暴露水平都很低，特异性IgE阳性率和阳性水平都不高。对其皮试阳性可能是因为和屋尘螨/粉尘螨的交叉反应引起的。 海南地区蟑螂过敏原暴露水平相对高，但至今未见有特异性IgE检测和交叉反应数据，故其临床重要性有待进一步研究 蟑螂过敏原在全国范围内的临床重要性也有待激发试验等进一步证实。 * * North Total n=2333 East Total n=1251 Western south Total n=1516 Southern coast Total n=1204 All regions Total n=6304 % 95%CI % 95%CI % 95%CI % 95%CI % 95%CI D. farinae 41.3 39.3-43.3 60.4a 57.7-63.1 78.2a, b 76.1-80.3 67.9a, b, c 65.2-70.5 59.0 57.8-60.3 D. pteronyssinus 38.3 36.3-40.2 59.4a 56.7-62.1 77.2a, b 75.1-79.3 68.8a, b, c 66.1-71.4 57.6 56.4-58.9 Blomia tropicalis 28.5 26.7-30.3 35.3a 32.6-37.9 54.9a, b 52.3-57.4 52.2a, b 49.3-55.0 40.7 39.5-41.9 Dog 15.0 13.6-16.4 11.8a 10.0-13.5 11.7a 10.1-13.3 17.2b, c 15.1-19.3 14.0 13.2-14.9 Cat 11.7 10.3-13.0 8.6a 7.1-10.2 8.4a 7.0-9.8 11.7b’, c 9.9-13.5 10.3 9.5-11.0 American cockroach 11.4 10.1-12.6 17.3a 15.2-19.4 17.4a 15.5-19.3 22.5a, b, c 2.0-2.5 16.1 15.2-17.0 Blatella germanica 9.8 8.6-11.0 9.9 8.3-11.6 13.0a, b’ 11.3-14.7 14.5a, b 12.5-16.5 11.5 10.7-12.3 Artemisia vulgaris 24.1 22.4-25.9 4.5a 3.3-5.6 4.0a 3.0-5.0 2.5a, b, c’ 1.6-3.4 11.3 10.5-12.0 Ambrosia artemisifolia 13.16 11.7-14.5 3.1a 2.1-4.1 3.0a 2.1-3.8 1.6a, b’, c’ 0.9-2.3 6.5 5.9-7.1 Mixed grass pollen 5.3 4.4-6.2 2.7a 1.8-3.6 2.6a 1.8-3.4 2.0a 1.2-2.8 3.5 3.1-4.0 Mixed tree pollen 4.0 3.2-4.8 1.3a 0.7-1.9 1.1a 0.6-1.7 1.2a 0.6-1.9 2.2 1.9-2.6 Mixed mould I 9.3