外周血中性粒细胞与淋巴细胞比率预测肝细胞癌患者肝切除术后的生存.ppt

* 外周血中性粒细胞与淋巴细胞比率预测肝细胞癌患者肝切除术后的生存:一项基于倾向性匹配的分析结果 SCI文章解析 Blood neutrophil-lymphocyte ratio predicts survival after hepatectomy for hepatocellular carcinoma: A propensity score-based analysis IF:2.787 Abstract AIM: To investigate whether an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) can predict poor survival in patients with hepatocellular carcinoma (HCC). 目的：研究中性粒细胞与淋巴细胞比值是否有预测肝细胞癌患者预后的作用 METHODS: We retrospectively reviewed 526 patients with HCC who underwent surgery between 2004 and 2011 方法：回顾性分析了526例在2004年到2011年行肝切除手术的病人 RESULTS: Preoperative NLR ≥ 2.81 was an independent predictor of poor disease-free survival (DFS,P 0.001) and overall survival (OS, P = 0.044).Compared with patients who showed a preoperative NLR 2.81 and postoperative increase, patients who showed preoperative NLR ≥ 2.81 and postoperative decrease had worse survival (DFS, P 0.001; OS, P 0.001). Among patients with preoperative NLR ≥ 2.81, survival was signifcantly higher among those showing a postoperative decrease in NLR than among those showing an increase (DFS, P 0.001; OS, P 0.001).When elevated, alpha-fetoprotein (AFP) provided no prognostic information, and so preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS whenever AFP levels are low or high. 结果：1.术前NLR ≥ 2.81 是无瘤生存和总生存的一个独立的预后因素 2. 相比于术前NLR2.81且术后NLR升高的患者，术前NLR2.81且术后NLR降低的患者的无瘤生 存与总生存更差（P0.001）。在NLR2.81的亚组中，术后NLR降低组的患者的无瘤生存与总生存比术后 NLR升高组的患者要好（P0.001）。 3.对于AFP预测肝癌预后的预测模型中，NLR是一个很好的预测模型的补充。 Conclusions Preoperative NLR ≥ 2.81 may be an indicator of poor DFS and OS in patients with HCC undergoing surgery. Preoperative NLR ≥ 2.81 may be a good complementary indicator of poor OS when elevated AFP levels provide no prognostic information 结论：对于根治性肝切除的肝细胞癌患者，术前NLR ≥ 2.81 是一个很好的预测预后的指标，特别是对于AFP没有预测能力的患者中，NLR是一个很好的补充指标 Definition (定义): NLR was calculated by dividing the neutrophil count by the lymphocyte count. Preoperative NLR was determined within 7 d