肥厚型梗阻性心肌消融.pptVIP

肥厚型梗阻性心肌病的化学消融术Percutaneous Transluminal Septal Myocardial Ablation of HypertrophicObstructive Cardiomyopathy 胡奉环 阜外心血管病医院 冠心病中心 Etiology of Hypertrophic Cardiomyopathy (HCM) Hypertrophic cardiomyopathy (HCM) is inherited as a Mendelian autosomal dominant trait. Estimated prevalence of 0.2% (0.16% in China). It is caused by mutations in 11 genes coding for sarcomeric proteins . Pathophysiology of HCM Ventricular hypertrophy Left Ventricular Outflow （LVOT）Pressure Gradient（PG) Diastolic dysfunction Arrhythmia Myocardial ischemia LVOTPG Left Ventricular Outflow Tract（LVOT） Pressure Gr