T细胞及其介导的细胞免疫应答幻灯片.ppt

* * * * * * * * * * * * * * * * Naive T cells Effector T cells Memory T cells Migration Preferentially to peripheral lymphoid tissues Preferentially to inflamed tissues Preferentially to inflamed tissues, mucosal tissues Frequency of cells responsive to particular antigen Very low High Low Effector functions None Cytokine secretion; cytotoxic activity None Cell cycling No Yes +/- Surface protein expression ? ? ? High-affinity IL-2 receptor Low High Low Peripheral lymph node homing receptor (L-selectin, CD62L) High Low Low or variable Adhesion molecules: integrins, CD44 Low High High Chemokine