癌生物学-肿瘤细胞周期调控.ppt

* * * * * The G1 checkpoint control mechanism ensures that everything is ready for DNA synthesis. The first checkpoint is located at the end of the cell cycles G1 phase, just before entry into S phase, making the key decision of whether the cell should divide, delay division, or enter a resting stage. Many cells stop at this stage and enter a resting state called G0 * * The restriction point is controlled mainly by action of the CKI p16 (CDK inhibitor p16). This protein inhibits CDK4/6 and ensures that it can no longer interact with cyclin D1 to cause cell cycle progression. In growth-ind