参麦注射剂不良反应流行病学特点研究.pdf

·临床研究· 临床药物治疗杂志 2013 年 7 月第 11 卷第 4 期 Clinical Medication Journal,July2013,Vol.11,No.4 参麦注射剂不良反应流行病学特点研究 1 2 2 2 刘庆 张晓朦 秦丹 吴嘉瑞 1 新疆医科大学附属中医医院药学部( 乌鲁木齐市830000) 2 北京中医药大学（北京 100102 ） 【摘要 】目的：分析参麦注射剂不良反应特点。方法：检索 1972-2010 年文献报道的参麦注射剂 不良反应，并应用独立样本t 检验等进行统计分析。结果：参麦注射剂的不良反应主要发生≥60 岁 的老年人中，不良反应的临床表现包括过敏性休克、全身过敏样反应、皮肤损害过敏反应等，主要发 生在用药30min 内，预后再激发阳性16 例(19.28%)。结论：临床应用参麦注射剂时应根据患者的情况, 特别关注再激发阳性，辨证用药, 并采取相应的防治措施。 【关键字 】参麦注射剂；不良反应；流行病学 【中图分类号 】R283 【文献标志码 】A doi:10.3969/j.issn.1672-3384.20 13.04.005 1 Epidemiological studies of adverse reaction induced by Shenmai injection Liu qing , 2 2 2 Zhang Xiao-meng , Oin Dan ,Wu Jia-rui . 1 Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University, Urumqi 830000,China; 2 Beijing University of Chinese Medicine ,Beijing 100102,China Abstract Objective: To analyze the characteristics of adverse drug reaction(ADR) induced 【 】 by Shenmai injection. Method: we collected reports of adverse drug reactions of Shenmai injection in national journals from 1972 to 2010, and do statistical analysis. Results: The ADR occurred mainly in more than 60 years old elderly patients, and ADR were anaphylactic shock and allergic reactions of multisystem and multiple organ. Allergic reactions mainly occurred within 30min after administration. There are 16 ADR cases(19.28%) rechallenging positive after treatment. Conclusion: Administration of Shenmai injection should base on the patients condition, and we should pay special attention to rechallenging positive, dia