2型糖尿病现代治疗.ppt

DISCUSSION POINTS: Data illustrate the incretin effect. The plasma insulin response to intravenous glucose was less than half of that seen after oral glucose ingestion, indicating that in addition to plasma glucose, alimentary mechanism(s) (incretins) regulate insulin secretion. An incretin is a substance released by the gut into circulation in response to food intake, which exhibits actions including glucose dependent enhancement of insulin secretion. SLIDE BACKGROUND: DISCUSSION POINTS: GLP-1, a product of the proglucagon gene of the intestinal L-cells, is released rapidly in response to m