专业培训资料乳腺癌辅助内分泌.pptVIP

* ER在氨基端和羧基端各有一个转录激活域，AF1和AF2，配体依赖性的AF1和配体非依赖性的AF2各自独立或相互协同发挥计划作用 ERE：雌激素反应元件 Eralfa能够通过经典的ERE途径活化基因转录。雌激素如雌二醇弥散于核中与Eralfa结合，雌激素结合的ER异构体变换空间构象导致其于Hsp90的分离，加上协同活化因子的作用使单体二聚化，促进ER的DNA结合区与靶基因上雌激素反应元件结合，启动转录机制，调控基因表达。 A schematic representation of the effect of the full agonist estradiol (E) on the estrogen receptor (ER) leading to full activation of DNA transcription The full agonist, estradiol, binds to the estrogen receptor in the cell cytoplasm The estrogen-ER complex has two activation functions, AF1 and AF2 The complex dimerizes and localizes to the cell nucleus, where it binds to the estr