红细胞和贫血 夏立.pptx

基 础 血 液 学红细胞与贫血Erythrocyte Anemia;;BLOOD;At a Glance;Objectives;Blood Cell Production;Stem cell;Reticulocyte no nucleus no organelles many polyribosomes larger than the mature RBC not concave Normally, 25 billion cells, which is 1% of circulating blood, are reticulocytes In severe anemia, many of these (3%) are released into the blood prematurely. ;骨髓红系定向细胞增殖及其最重要受体的理论模型 EPO：促红细胞生成素；GM-CSF：粒-巨核细胞集落刺激因子；IL3：白介素3； Transferrin: 转铁蛋白；Fibronectin:纤连蛋白;Too few RBCs leads to tissue hypoxia ;Hypoxia Inducible Factor (HIF);Erythropoietin (EPO（促红细胞生成素）) 34,000 Da, Glycoprotein Released by the kidney