mFOLFOX6方案与PF方案同步放疗治疗非手术食管癌的近期疗效观察.docx

mF0LF0X6方案与PF方案同步放疗治疗非手术食管癌的近期疗效 观察 【摘要】目的對比非手术食管癌患者采取mF0LF0X6方案同 步放化疗与传统PF方案同步放化疗的疗效差异。方法60例II/ m期非手术食管鳞癌患者，随机分为试验组(27例)和对照 组(33例)。两组均釆用三维适形放疗(3D-CRT)。试验组放疗 期间予以mF0LF0X6方案同步化疗，对照组放疗期间予以PF方 案同步化疗。分析两组近期疗效、治疗毒性反应。结果试验组 近期总有效率为92. 59%,高于对照组的75. 76%,但差异无统 计学意义(P>0. 05)o两组主要毒性为骨髓抑制、消化道反应及 神经毒性反应。骨髓抑制主要表现为白细胞减少，其中试验组 III?IV度骨髓抑制发生率为22. 2% (6/27),对照组为27. 3% (9/33),比较差异无统计学意义(P>0. 05)o消化道反应主要 表现为放射性食管炎、恶心、呕吐。两组均未发生III度以上食管 炎；试验组恶心、呕吐发生率29. 6% (8/27)对照组为60. 6% (20/33),比较差异有统计学意义(P二0. 017<0. 05)o两组外周 神经毒性均为轻度，试验组发生率为66. 7% (18/27),对照组 为57. 6% (19/33),比较差异无统计学意义(P>0? 05)o所有不 良反应经对症治疗后均可缓解，患者能良好耐受。结论与传统 PF方案同步放化疗比较，mFOLFOX6方案同步放化疗治疗非手术 食管鳞癌患者近期总有效率较高，近期疗效好，不良反应可耐 受，值得进一步研究。 【关键词】非手术食管癌；同步放化疗；mF0LF0X6方案； PF方案 DOI： 10.14163/j. cnki. 11-5547/r. 2017. 08. 012 【Abstract 】 Objective To compare difference of curativeeffectsbetween curative effects between mF0LF0X6 regimen radiochemotherapy and PF regimen in concurrent radiochemotherapy for non-operative esophagus cancer patie nts. Met hods A to tai of stage II /ITT non-opera tive esophagus squamous carcinoma patients were randomly divided into experimental group (27 cases) and control group (33 cases)? Both groups received three-dimensional conformal radiation therapy (3D-CRT)? The experimentai group received mF0LF0X6 regimen radiochemotherapy in treatment, and the control group received PF regimen in concurrent radiochemotherapy instead? Analysis was made on short-term curative effect and toxic reactions in treatment in the two groups? ResuIts The experimental group had higher short-term total effective rate as 92. 59% than 75. 76% in the control group, while their difference had no statistical significance (P>0.05)? Main toxic reactions in both groups included mye1osuppression , gastrointestinal reactions and neurotoxic reactions , with leucopenia as the main manifesta tion in myelosuppression. The experimental group had incidence of grade III?IV myelosuppression as 22.2% (6/27), which was 27.3% (9/33) in the control group, and t