甲状腺癌PBL研究.pptVIP

Multiinstitutiona? phase?2?trial?of?pazopanib?monotherapy?in?advanced?anaplastic?thyroid?cancer. J Clin Endocrinol Metab.?2012 Sep;97(9):3179-84. Epub 2012 Jul 6. 靶向药物-帕唑帕尼2 Sixteen trial patients were enrolled; 15 were treated,11 of 15 had progressed through prior systemic therapy. Four patients required one to two dose reductions; severe toxicities (grades 3) were hypertension (13%) and pharyngolaryngeal pain (13%). Treatment was discontinued because of : disease progression (12 patients), death due to a possibly treatment-related tumor hemorrhage (one patient), and intolerability (radiatio