微生物学美国IndianaUniversityPurdueUniversi项ty授课03.pptVIP

Strategies for Studying Microbial Pathogenesis BIOL 533 Lecture 3 Choosing an Animal Model Pathogen may not affect animal at all -OR- may give different symptoms Given disease may have a number of animal models, none of which fully satisfies characteristics of disease Choosing an Animal Model One model may show certain aspects of disease, but not another Different models may rely on different routes of introducing pathogen; e.g.: Bordetella pertussis Intracranial Interperitoneal Respiratory aspiration Choosing an Animal Model Ideally, want model to: Use same route as human disease