微生物学美国IndianaUniversityPurdueUniversit生y授课06.pptVIP

Phagocytosis and the Interactionsof Various Phagocytes BIOL 533 Lecture 6 Leukocyte Chemotaxins Types of chemotaxins C5a attracts neutrophils and monocytes Made by bacteria Peptide clipped off N-terminus (beginning with N-formylmethionine) during peptide maturation after protein synthesis Made by bacteria and nucleated blood cells Leucotrienes—lipid products of cell membrane metabolism Leukocyte Chemotaxins Function of chemotaxins Enhance and direct motility of phagocytic cells To a limited extent, oxidative metabolism of phagocytic cells Opsonization and Opsonins General aspects Substanc