课件：W肿瘤免疫学.ppt

Why Inflammatory monocytes:excessive is a hallmark of diseases. Therefore, targeting these cells could be of therapeutic value. Why Inflammatory monocytes (LY6Chi) :CCR2hi, non-inflammatory monocytes:CCR2low. Ccr2–/– mice：inflammation↓. Therefore, targeting of CCR2 could selectively inhibit inflammatory monocyte recruitment. How A lipid nanoparticle that encapsulated a short interfering RNA (siRNA) that targets Ccr2 mRNA (termed siCCR2). By labelling the siRNA with a near-infrared fluorochrome, siCCR2 could be tracked. Following intravenous injection, siCCR2 was rapidly cleared from