肿瘤代谢重编程与药物耐药性.PDFVIP

《中国医学前沿杂志（电子版）》2019 年第11 卷第2 期 ● ●   23  重点号专题  DOI ：10.12037/YXQY.2019.02-06 肿瘤代谢重编程与药物耐药性 1 2,3,4 姚利昂 ，胡泽平 （1．清华大学　生命科学学院，北京　100084 ；2 ．清华大学　药学院，北京　100084 ； 3 ．清华大学　生命科学联合中心，北京　100084 ；4 ．北京市结构生物学高精尖创新中心，北京　100084） 【摘要】代谢重编程是肿瘤细胞的重要特征之一。为了满足快速增殖对于物质、能量以及氧化还原力的需求，肿瘤细胞对 其代谢通路进行重编程。代谢重编程使细胞内外特定代谢物的水平或种类发生变化，这一变化通过影响基因表达、细胞状 态以及肿瘤微环境而促进肿瘤生长。葡萄糖代谢、谷氨酰胺代谢及脂质代谢是肿瘤细胞中变化最显著的代谢通路，靶向代 谢重编程可以显著抑制肿瘤生长并促进凋亡。肿瘤耐药是目前肿瘤治疗中的热点和难点，代谢重编程与肿瘤耐药密切相关， 靶向耐药肿瘤相关代谢过程可以逆转肿瘤对药物的抗性。 【关键词】肿瘤代谢；代谢重编程；Warburg效应；耐药 Metabolic reprogramming and cancer drug resistance 1 2,3,4 YAO Li-ang , HU Ze-ping (1. School of Life Sciences, Tsinghua University, Beijing 100084, China; 2. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China; 3. Tsinghua-Peking Joint Center for Life Sciences, Beijing 100084, China; 4. Beijing Advanced Innovation Center for Structural Biology, Beijing 100084, China) Corresponding author: HU Ze-ping, E-mail: zeping_hu@tsinghua.edu.cn Abstract 【 】 Altered metabolism is one of the hallmarks of cancer. Metabolic reprogramming contributes to energy acquisition, biomass synthesis and redox balance maintaining for cell survival and rapid growth. Metabolic reprogramming results in the change of specific metabolites level or type within or out of cell, which promotes tumor growth by affecting gene expression, cell status, and tumor microenvironment. Glucose metabolism, glutamine metabolism, and lipid metabolism are the most significant altered metabolic pathways in tumor cells. Targeting altered metabolic process can significantly suppress tumor growth and promote tumor cell apoptosis. Drug resistance remains as a great in cancer therapy. The alter