细胞膜磷脂与肿瘤侵袭转移及靶向治疗的相关性研究进展.pdf

2015 42 6  Cancer Res Prev Treat,2015,Vol.42,No.6 631 肿瘤防治研究 年第 卷第 期 · · doi:10.3971/j.issn.1000-8578.2015.06.022 ·综  述· 细胞膜磷脂与肿瘤侵袭、转移及靶向治疗的 相关性研究进展 郑蕙，张宏颖 Progress of Correlation of Cell Membrane Phospholipids with Invasion, Metastasis and Targeted Therapeutics of Tumor ZHENG Hui, ZHANG Hongying Department of Pathology Forensic Medicine, College of Basic Medical Sciences, Dalian Medical University, Dalian 116044, China Corresponding Author: ZHANG Hongying, E-mail: irisliupai@163.com Abstract: Invasion and metastasis are the signs of tumor progression and give rise to a major problem in clinical treatment of cancer and a main cause of death of cancer sufferers. Phospholipids are a class of lipids that not only are major components of cell membrane, but also take part in various biological functions of tumor cells such as proliferation, migration, adhesion, signaling, apoptosis and cell cycle regulation. In this review, the discussion focuses on the research progress of the correlation of cell membrane phospholipids with invasion, metastasis and targeted therapy of tumor. Components and distribution of membrane phospholipids, metabolites of phospholipids, phospholipases, and phospholipid binding proteins play major roles in tumor cell membrane fluidity, adhesion, apoptosis, proliferation, invasion, metastasis, angiogenesis, and lymphoangiogenesis. As targets, cell membrane phospholipids and their metabolites will have a broad prospect for targeted therapy of malignant tumors. Key words: Membrane phospholipid; Tumor metastasis; Targeted therapy 摘  要: 侵袭和转移是肿瘤进展的标志，是肿瘤临床治疗的难题及肿瘤患者死亡的主要原因。磷脂是 生物膜的重要物质基础，参与肿瘤细胞增殖、运动、黏附、凋亡、信号转导、细胞周期调节等活动。 本文对膜磷脂在肿瘤侵袭、转移、靶向治疗中的作用研究进展进行了综述。细胞膜磷脂成分及分布、 磷脂代谢产物、磷脂酶及磷脂结合蛋白在肿瘤细胞膜流动性、黏附、凋亡、增殖、侵袭、转移、血管 及淋巴管形成中具有重要作用，以细胞膜磷脂及其代谢产物为靶点治疗恶性肿瘤具有广阔前