aosd诊治进展成人Still病诊治进展.ppt

* 38例发热的AOSD患者（10M，28F，39.3y/o） 12例存在明确的细菌感染 26例活动的无感染AOSD患者（活动评分≥3） 符合Yamaguchi标准 检测PCT、CRP、IL-6、TNF-α * 目前至少有7套诊断标准，大多数都是上述典型症状和化验的组合， but Who is the best？ Peking Union Medical College Hospital * 参考文献 18. Godeau B, Leport C, Perronne C, Salmon-Ceron D, Vilde JL, Kahn MF. Long term evolution of adult onset Still's disease seen in an infectious diseases department. Ann Rheum Dis 1991;50:968. 19. Fujii T, Akizuki M, Kameda H, et al. Methotrexate treatment in patients with adult onset Still's disease--retrospective study of 13 Japanese cases. Ann Rheum Dis 1997;56:144-8. 20. Vignes S, Le Moel G, Fautrel B, Wechsler B, Godeau P, Piette JC. Percentage of glycosylated serum ferritin remains low throughout the course of adult onset Still's disease. Ann Rheum Dis 2000;59:347-50. 21. Kraetsch HG, Antoni C, Kalden JR, Manger B. Successful treatment of a small cohort of patients with adult onset of Still's disease with infliximab: first experiences. Ann Rheum Dis 2001;60 Suppl 3:iii55-7. 22. Asherson RA, Pascoe L. Adult onset Still's disease: response to Enbrel. Ann Rheum Dis 2002;61:859-60; author reply 60. 23. Hamidou MA, Denis M, Barbarot S, Boutoille D, Belizna C, Le Moel G. Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease. Ann Rheum Dis 2004;63:605. 24. Vasques Godinho FM, Parreira Santos MJ, Canas da Silva J. Refractory adult onset Still's disease successfully treated with anakinra. Ann Rheum Dis 2005;64:647-8. 25. Aarntzen EH, van Riel PL, Barrera P. Refractory adult onset Still's disease and hypersensitivity to non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 inhibitors: are biological agents the solution? Ann Rheum Dis 2005;64:1523-4. 26. Ahmadi-Simab K, Lamprecht P, Jankowiak C, Gross WL. Successful treatment of refractory adult onset Still's disease with rituximab. Ann Rheum Dis 2006;65:1117-8. 27. Arlet JB, Le TH, Marinho A, et al. Reactive haemophagocytic syndrome in adult-onset Still's disease: a report of