密闭舱室内胸腹部对冲击波动态响应规律的研究.doc

密闭舱室内胸部对冲击波动态响应规律的研究 康建毅1,2 , 彭承琳1, 赖西南2, 黄小龙2, 赵兴虎2（1 重庆大学生物工程学院，重庆400044 ;2 第三军医大学大坪医院野战外科研究所第六研究室，重庆 400042） 提 要： 目的：探讨密闭舱室内大鼠胸部对不同大小爆炸冲击波的动力学响应过程，分析胸壁的粘弹性运动过程及其与伤情间的关系。方法：在密闭舱室内用不同当量的点爆源爆炸对大鼠致伤，采用REDLAKE-HE高速摄影机观察胸壁的运动情况，记录冲击波超压，分析大鼠损伤的伤情。结果 胸部变形量、胸壁向内最大速度与损伤严重程度指数ASII有一定的相关性（r＝0.96778 ，p＝0.03222；r＝0.96881，p＝0.03119）。胸壁运动对内部器官造成损伤机制主要是粘性损伤机制。结论：胸壁的变形运动过程是造成胸部损伤的关键因素之一。密闭舱室内胸壁向内最大速度与损伤严重程度指数ASII有较好的相关关系，是预测冲击伤伤情的可靠参数。 关键词：密闭舱室；胸部；高速摄影术；冲击波；动态响应 Dynamic response of chest to blast wave research in airtight closed chamber in rats KangANG Jian-yi1 ,2 , PengENG Cheng-lin1, , LaiAI Xi-nan2, , HuangUANG Xiao-long2, , ZhaoHAO Xin-hu2 (1College of Bioengineering, Chongqing University, Chongqing 40004 ；; 2State Key Laboratory of Trauma, Burns, and Combined Injury, Department 6, Research Institute Oof Surgery Research , Third Military Medical University , Chongqing 400042, China) Abstract　Objective: To explore the dynamic response of rat chest wall to different blast waves of mice and its relationship with the injury severity in airtight closed chamber. Methods: Different spherical explosives with different explosive energy equal to 80, 200, 400 or 600 mg TNT were used to produce blast waves to 4 groups of rats (n=10) respectively in a closed chamber. All rats were anesthetized and with their chest placed 11.5 cm from the denotator. different detonator were denotated in airtight chamber ,A REDLAKE-HE high-speed camera was used to recordobserved the movement of chest wall and the over-pressure of blast wave. The rat injury were analyzed with adjusted severity of injury index (ASII) and light and electron microscopyof mice by REDLAKE-HE high-speed camera, noted overpressure of blast wave ,analyzed injury lever of mice .Results: Chest deformation, and the highest speed of peak inward chest wall inward speed were correlated with Adjusted Severity of Injury Index in some degrees（ (r=＝0.967 78 ，, pP＝=0.032 22；; r＝=0.968 81，, Pp＝=0.031 19）). Thoracic Oorgans injury due to inwa