Mol Pharmacol-2014-Free-mol.113.090563英文文献资料.pdf

Molecular Pharmacology Fast Forward. Published on April 22, 2014 as doi:10.1124/mol.113.090563 MOL #90563 Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor R. Benjamin Free, Lani S. Chun, Amy E. Moritz, Brittney Miller, Trevor B. Doyle, Jennie L. Conroy, Adrian Padron, Julie A. Meade, Jingbo Xiao, Xin Hu, Andrés E. Dulcey, Yang Han, Lihua Duan, Steve Titus, Melanie Bryant-Genevier, Elena Barnaeva, Marc Ferrer, Jonathan A. Javitch, Thijs Beuming, Lei Shi, Noel Southall, Juan J. Marugan, and David R. Sibley Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD (RBF, LSC, AEM, BM, TDB, JLC, AP, JAM, DRS) National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD (JX, XH, AED, ST, MBG, EB, MF, NS, JJM) Center for Molecular Recognition and Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY. Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY (YH, LD, JAJ) Schrödinger Inc., New York, NY (TB) Department of Physiology and Biophysics and Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY (LS) 1 Copyright 2014 by the American Society for Pharmacology and Experimental Therapeutics. MOL #90563 Running Title: G Protein-Biased D Receptor Agonist 2 Corresponding Author: R. Benjamin Free, Ph.D. Molecular Neuropharmacology Section National Institute of Neurological Disorders and Stroke, National Institutes of Health 5625 Fishers Lane, Room 4S-04 Bethesda, MD 20892-940