瑞替普酶和尿激酶静脉溶栓治疗肺栓塞疗效和安全性的Meta分析.PDF

()2016 10 10 19 Chin J Clinicians(Electronic Edition),October 1,2016,Vol.10,No.19 2883 Meta 董娅 1,2 赵钰玲 1,2 李建英 1 PubmedMedlineCNKI Revman 5.3 Meta 7 P=0.002 P=0.02 Meta A Meta-analysis on reteplase and urokinase thrombolytic therapy in treatment of patients with 1,2 1,2 1 1 pulmonary embolism Dong Ya , Zhao Yuling , Li Jianying . Department of Respiratory Disease, Xian Central Hospital Affiliated to Medical Colleg e of Xian Jiaotong University, Xian 710000, China; 2Medical College of Yanan University, Yanan 716000, China Corresponding author: Li Jianying, Email: 128129130@ Abstract Objective This study is conducted to evaluate the efficacy and safety of reteplase and urokinase thrombolytic therapy in treatment of patients with pulmonary embolism. Methods Such data based as Pubmed, Medline, CNKI, wangfang data and so on. Collected the randomized controlled trials about the treatment with reteplase and urokinase thrombolytic therapy in treatment of patients with pulmonary embolism. Revman 5.3 software was used for Meta-analysis. Results 7 studies were involved in. There were significant difference in the effective rate between the two groups (P=0.002). The effective rate was higher in the group of reteplase than urokinase; thrombolysis with reteplase was more effective in reducing pulmonary artery pressure and increasing oxygen partial pressure. There were significant difference in the bleeding rate between the two groups (P=0.02). The group of reteplase in the bleeding rate was lower than the group of urokinase. Conclusion Compared with urokinase, reteplase was more effective and less risky of bleedi