Design and characterization of synthetic fungal-bacterial consortia for direct production of isobutanol from cellulosic biomass英文学习资料.pdfVIP

Design and characterization of synthetic fungal-bacterial consortia for direct production of isobutanol from cellulosic biomass a a b a a c d Jeremy J. Minty , Marc E. Singer , Scott A. Scholz , Chang-Hoon Bae , Jung-Ho Ahn , Clifton E. Foster , James C. Liao , and Xiaoxia Nina Lina,1 aDepartment of Chemical Engineering and bCellular and Molecular Biology Ph.D. Program, University of Michigan, Ann Arbor, MI 48109; cDepartment of Energy Great Lakes Bioenergy Research Center, Michigan State University, Lansing, MI 48824; and dDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095 Edited by Lonnie O. Ingram, University of Florida, Gainesville, FL, and approved July 12, 2013 (received for review October 30, 2012) Synergistic microbial communities are ubiquitous in nature and In contrast to the CBP “superbug” paradigm, microbes live in exhibit appealing features, such as sophisticated metabolic capa- synergistic communities in most natural environments in which bilities and robustness. This has inspired fast-growing interest in individual species with specialized roles cooperate to survive and engineering synthetic microbial consortia for biotechnology de- thrive together (3). Natural microbial consortia hold many ap- velopment. However, there are relatively few reports of their use pealing properties in a bioprocessing context, such as stability, functional robustness, and the ability to perform complex tasks in real-world applications, and achieving population stability and (3, 4).