Towards synthetic microbial consortia for bioprocessing英文学习资料.pdfVIP

Available online at Towards synthetic microbial consortia for bioprocessing 1 1 1,2 Jasmine Shong , Manuel Rafael Jimenez Diaz and Cynthia H Collins The use of microbial consortia for bioprocessing has been where ubiquitous communities consist of multiple popu- limited by our ability to reliably control community composition lations that coexist and carry out complex chemical pro- and function simultaneously. Recent advances in synthetic cesses and physiological functions to enable survival of the biology have enabled population-level coordination and control community [2,3]. of ecosystem stability and dynamics. Further, new experimental and computational tools for screening and Early innovators in the fields of biochemical and bio- predicting community behavior have also been developed. The logical engineering recognized the potential of microbial integration of synthetic biology with metabolic engineering at consortia for bioprocessing and biotechnological appli- the community level is vital to our ability to apply system-level cations. Yet while there are rare examples of success approaches to building and optimizing synthetic consortia for (recently reviewed [4]), mono-culture systems continue bioprocessing applications. This review details new methods, to dominate the landscape of industrial bioprocessing. tools and opportunities that together have the potential to The major barrier to using communities for bioprocessing enable a new paradigm of bioprocessing using synthetic is that it requires simultaneous control of both the i