肿瘤免疫学---山东大学精品课程建设工作.pptVIP

cytokine positive effectors: IFN TNF IL (2,7,12,18) CSF negative effectors: IL-10 TGF-β CD4+ T cell CD8+ T cell Assist to activate CTL, B cells, NK, macrophages Secret cytokines：IL-2，IFN-γ TNF-β Bind tumor antigen to kill tumor cells Secreting cytokine: TNF-αTNF-βIFN-γ NK Th a You! Tumor Immunology T cells Team members: 徐桂香 王莹 张爱涓 张璐娴 赵云鹏 朱玉 Tumor * Concept： Tumor: excrescence(赘生物 )formed by normal tissue cells’ unusual proliferation. Tumor * Forming Mechanism: Mutation of protooncogen and anti-ontigen Tumor * Classification: non-blood cell type blood cell type autonomic type virus associated type T cell * αβ T cells: CD8 T cells CD4 T cells NKT γδ T cells *  A necessary system in the immune surveillance against cancer ?? T cell γδ T cell * Characters: exit in skin epidermis and mucosal epithelium don’t require antigen to be presented by MHC(CD3 CD2 CD16 CD25……） molecular recognition (directly): HSP、lipid antigen、viral antigen、small phosphoration non-peptide molecule function: anti-infection、 anti-virus、 immune regulation * Circulate ?? T cell NCAM Resistant ?? T cell Resistant ?? T cell Circulate ?? T cell NK cell receptor protein1A 跨内皮细胞迁移 recirculation * ?? T cell Destroyed tissues CCR1 CCR5 chemokine chemotaxis Ag Recognition * * ??T cells TCR Tumor cell Recognized substances :自然配基-如含磷的尿苷或胸苷，异戊基或含异戊二烯基的磷酸化的化合物等。 They are excessive expressed in the destroyed tissues and tumor cells Ag Recognition * * ?? T cell epithelial tumor cells NKG2D MICA MICB Ag Recognition * V ?1 T can recognize the tumor cells