如何改变HER2阳性早期乳腺癌患者的未来.pptVIP

This slide shows a greater number of adverse events, SAEs and fatal AEs with trastuzumab The nature of the fatal AEs don’t howeverseem to have any causal significance – cerebral haemorrage,CVA intestinal obstruction, road traffic accident etc 10% of patients stopped trastuzumab prematurely And finally this shows the cardiac safety data – reviewed by the Cardiac Advisory Board- The only cardiac death was paradoxically in the Observation arm The risk of severe CHF was low 0.6% The risk of any CHF was also reasonably low with a 1.9% difference between the 2 Arms – well within the 4% stopping ru