五洲会何作祥-核心脏病学现状与进展.pptVIP

五洲会何作祥-核心脏病学现状与进展.ppt

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* * Imaging in Coronary Artery Disease Changing roles Coronary stenosis (coronary angiography, CTA)? myocardial ischemia (SPECT, PET, stress echo) ? Changing strategy Accuracy of Noninvasive Test for Diagnosis of CAD No. of Studies No. of Patients Sensitivity Specificity Exercise ECG 147 24047 68 77 Exercise Perfusion Imaging 2 28751 89 80 Pharmacological Stress Scintigraphy 11 1000 85 91 Circulation 2000;102:126 Gupta et al, 1992 腺苷负荷试验心肌灌注显像多中心临床试验 田月琴,等,中华心血管病杂志,2005 Aden Rest Aden Rest Aden Rest Can Gated SPECT improve sensitivity for CAD detection? Part 0. Introduction to Nuclear Medicine * ECG-GATED MYOCARDIAL PERFUSION Gated SPECT vs. Cine MRI Wang F, et al. Eur J Nucl Med Mol Imaging, 2009 Specificity of Stress TI-201 and Tc-99m Sestamibi SPECT for CAD Detection in Women Stenosis ?50% (n=51) Stenosis ?70% (n=64) p=0.002 p=0.0004 p=0.05 NS p=0.02 NS Adapted from Taillefer et al. J Nucl Med 1996;37:69P. 70.6 86.3 94.1 67.2 84.4 92.2 0 10 20 30 40 50 60 70 80 90 100 Tl-201 Tc-99m Sestamibi Gated Tc-99m Sestamibi Specificity (%) Examples of Coronary Artery Scans Normal Condition Moderate Calcification Severe Calcification 0% 0% 2.7% 10.8% 48.3% 0 10 20 30 40 50 0 11-100 101-399 400 EBT Baseline Calcium Score % with +SPECT (n=17) (n=37) (n=93) (n=89) (n=10) 1-10 246 patients all asymptomatic except 34 with atypical CP 58 + 10 years 75% with 2 or more RF He et. al Circulation 2000;101:244-51 EBT Calcium Score and SPECT Thallium Stress Testing Clinical Characteristics (N=706) of Patients who Underwent CTA and SPECT * N (%)/average Age 56.1±9.9 Male 450 (63.7%) Body Mass Index 25.1* Diabetes 102 (14.4) Hypertension 388 (55.0) Hyperlipidemia 407 (57.6) Smoking 273 (38.7) Family History of CAD 165 (23.4) Symptoms Asymptomatic 118 (16.7) Atypical chest pain 476 (67.4) Typical chest pain 112 (15.9) Accuracy of luminal stenosis by coronary CTA for detecting abnormal MPI * Stenosis Sensitivity* Specificity* PPV* NPV** Patients’ Level ≥50% 80.2 56.7 21.5 95.1 ≥75%

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