脑血栓形成合并阻塞性睡眠呼吸暂停低通气综合征患病率调查及对神经功能障碍的影响.doc

脑血栓形成合并阻塞性睡眠呼吸暂停低通气综合征患病率调查及对神经功能障碍的影响 上海市静安区老年医院200042 任蕾 王凯 杜井波 李珍 李庆云 [摘要] 目的 探讨脑血栓形成患者合并阻塞性睡眠呼吸暂停低通气综合征的患病情况及对认知和神经功能障碍的影响。 方法 对46例脑血栓形成患者及32例对照组采用多导睡眠图(PSG)检测，并行MMSE评分、中国神经功能缺损评定量表及欧洲脑卒中量表评分。进一步对相关结果进行对比分析。 结果 脑血栓形成组睡眠呼吸暂停低通气指数(AHI)显著高于对照组（P0.05）。脑血栓形成患者OSAHS的患病率高于对照组(52.2% vs 25.0%,P0.01）。脑血栓形成合并OSAHS的患者MMSE评分较单纯OSAHS患者明显下降（P＜0.01）。脑血栓形成合并OSAHS患者中国神经功能缺损评定量表及欧洲脑卒中量表评分比单纯脑血栓形成者明显下降（P＜0.01）。 结论：脑血栓形成患者OSAHS的患病率明显高于对照组。合并OSAHS的脑血栓形成患者的认知功能及神经功能下降。 关键词：脑血栓形成；阻塞性睡眠呼吸暂停低通气综合征 ; MMSE评分；中国神经功能缺损评定量表；欧洲脑卒中量表 Prevalence of cerebral thrombosis combined with obstructive sleep apnea-hypopnea syndrome and influence on neurological and recognition function Lei Ren 1 ，kai Wang2 , Jingbo Du 1， Zhen Li1 ,Qingyun Li 3 1 Department of Respiratory Medicine, Shanghai Jingan Geriatric Hospital, 200042 ,China. 2 Department of Rehabilitation Medicine, Shanghai Jingan Geriatric Hospital, 200042 ,China. 3 Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025 ,China. [Abstract]Objective: To investigate the prevalence of cerebral thrombosis combined with obstructive sleep apnea-hypopnea syndrome, and the influence on recognition and neurological function. Methods: 46 patients with cerebral thrombosis and 32 controls were tested by polysomnography (PSG). MMSE, European stroke scale and Chinese Neurological Impairment Scale were recorded and the influence of OSAHS were analyzed. Results: AHI of patients with cerebral thrombosis are significantly higher than those in control group (52.2% vs 25.0%, P0.05）. The score of MMSE and European Stroke Scale and Chinese Neurological Impairment Scale of patients with cerebral thrombosis combined with OSAHS are significantly lower than those of cerebral thrombosis without OSAHS. Conclusion: Higher prevalence of cerebral thrombosis combined with OSAHS were found in patients. Combining with OSAHS has influence on recognition and neurological function of patients with ce