535例慢性荨麻疹临床流行病学特征分析.docVIP

535例慢性荨麻疹临床流行病学特征分析 罗 婕，宋志强，钟 华，尹 锐，黄秀英，李垚莹，程良金，向明明，王 莉，郝 飞 （400038 重庆，第三军医大学西南医院皮肤科） [摘要] 目的 了解慢性荨麻疹（chronic urticaria，CU）临床流行病学特征。方法 以2010年1月1日至9月30日，对临床确诊为CU的535例患者进行问卷调查。调查数据录入EpiData数据库，运用SPSS 13.0软件进行统计学分析。结果 共收到有效问卷535例，其中男性204例，女性331例，年龄（34.4±14.0）岁，初发年龄(30.6±14.8)岁，以20～40岁多见。诱发因素中物理因素94例（17.6%），药物23例（4.3%），食物29例（5.4%），精神因素39例（7.3%），工作压力9例（1.7%），蚊虫叮咬24例（4.5%）, 其他54例（10.0%），无明显诱因263例（49.2%）。临床分型中最常见是慢性自发性荨麻疹（chronic spontaneous urticaria，CSU）294例（55.0%），其次皮肤划痕症120例(22.4%)，未发现延迟压力性、震动性和运动诱发性荨麻疹。CU伴血管性水肿105例 (19.6%)，其中，女性70例（21.1%），CSU 76例（25.9%）。自体血清皮肤试验（ASST）总阳性率为49.6%。结论 CU发病以青壮年为主，临床表现形式多样，伴发血管性水肿并非少见。关注CU的临床流行病学特征，有利于指导临床治疗。 [关键词] 慢性荨麻疹；临床流行病学；特征 [中图法分类号] [文献标志码] A An epidemiological signature analysis of 535 cases with chronic urticaria Luo Jie,Song Zhiqiang,Zhong Hua，Yin Rui，Huang Xiuying，Li Yaoyin，Cheng Liangjing，Xiang Mingming，Wang Li，Hao Fei(Department of Dermatovenere-ology,Southwest Hospital,Third Military Medical University,Chongqing 400038，China) [Abstract] Objective To investigate epidemiological features of chronic urticaria (CU). Methods A survey was conducted in our hospitals from January to September2010 in Chongqing. Subjects were received physical examination by dermatologists and required to fulfill the self-report questionnaires. EpiData and SPSS13.0 were utilized for statistical analysis.Results Totally, 535 subjects participated in this survey.Of them, 204 were male and 331 were female with a mean age of （34.4±14.0）years. The average age of subjects with CU at first was(30.6±14.8) years. The prevalence of CU peaked in patients aging from 20 to 40 years. The self-reported eliciting factors of urticaria were as follows: physical stimuli 94(approximately 17.6%), drugs 23（4.3%）,foods29（5.4%）, mental factor39（7.3%），working pressure 9（1.7%），mosquito 24（4.5%）,others 54（10.0%）,whereas 263（49.2%）of the participants could not identify any trigger.The most common type was chronic spontaneous urt