阿卡波糖与伏格列波糖比较治疗2型糖尿病的系统评价.pdfVIP

重庆医科大学硕士研究生学位论文 意义。与伏格列波糖比较，阿卡波糖的不良反应发生率更高 ［OR=0.29， 95%CI （0.17，0.51 ），P ＜0.001 ］。 结论：与伏格列波糖相比，阿卡波糖在控制 2 型糖尿病 PBG 、HbA1c 、 FBG 、TC 和 TG 方面的效果相似。与伏格列波糖相比，阿卡波糖的胃 肠道不良反应发生率更高。 关键词：阿卡波糖；伏格列波糖；α-糖苷酶抑制剂；2 型糖尿病； 系统评价 3 万方数据 重庆医科大学硕士研究生学位论文 ACARBOSE VERSUS VOGLIBOSE IN THE TREATMENT OF TYPE 2 DIABETS MELLITUS: A SYSTEMATIC REVIEW ABSTRACT Objective:To systematically evaluate the efficacy and safety of acarbose versus voglibose in treatment of type 2 diabets mellitus. Methods:The databases were electronically retrieved,including The CochraneLibrary, PubMed,OVID,MEDLINE,EMBASE,CBM,CNKI, VIP and Wan Fang (by the end of August 2014).We also manually searched papers from related magazines and conference proceedings. Then we assessed the quality of included studies, extracted the data from them with the evaluation method recommended by system evalu -ation manual. Finally,stastical analysis of data obtained using the RevMan 5.2 software. Results:A total of 605 articles were retrieved, but only 10 rando -mized controlled trials were finally included. The results of meta-ana -lyses showed that: compared with acarbose and voglibose group there was no significant difference to reduce 2h PBG(2h Postprandial blood glucose)[MD=-0.04,95%CI(-0.43,0.35),P=0.73], FBG(Fasting blood glucose)[MD=-0.04,95%CI(-0.43,0.35)] ,HbA1c(glycoylated hemo glo